Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24255322 | 0.93 | LRRK2 (0.58) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255507 | 0.93 | LRRK2 (0.64) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255315 | 0.88 | ALK (0.67) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255227 | 0.85 | LRRK2 (0.55) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255508 | 0.85 | ALK (0.64) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255244 | 0.84 | TNK2 (0.58) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255321 | 0.84 | ALK (0.58) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255302 | 0.82 | ALK (0.77) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255323 | 0.81 | ALK (0.57) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255319 | 0.79 | ALK (0.64) | LRRK2ALKJAK2SRCTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036312-A2 | INHIBITORS OF ACK1/TNK1 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |