Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830312 | 0.91 | KDM4E (0.36) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL17732326 | 0.91 | KDM4E (0.36) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL17712561 | 0.91 | KDM4E (0.36) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL658030 | 0.89 | KDM4E (0.50) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL691260 | 0.89 | KDM4E (0.50) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL660798 | 0.89 | KDM4E (0.50) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL6586194 | 0.84 | SLC6A1 (0.49) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL2423420 | 0.83 | GABRP (0.38) | KMT2ACYP2D6SMN1; SMN2TSHRNOS2 | |
| SCHEMBL659836 | 0.81 | MAPT (0.38) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL661356 | 0.81 | MAPT (0.38) | KDM4EMAPTKMT2AATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364087-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | Oncotherapy Science, Inc. (JP) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010051085-A1 | 7-HYDROXY-BENZOIMIDAZOLE-4-YL-METHANONE DERIVATIVES AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2010-05-06 | — | — | WO | disclosed |
| EP-1615930-A2 | TRIAZOLOTRIAZINES AND PYRAZOLOTRIAZINES USEFUL AS A2A ADENOSINE RECEPTOR ANTAGONISTS | Biogen Idec MA, Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092170-A2 | TRIAZOLOTRIAZINES AND PYRAZOLOTRIAZINES USEFUL AS A2A ADENOSINE RECEPTOR ANTAGON ISTS | BIOGEN IDEC MA INC. (US) | 2004-10-28 | — | — | WO | disclosed |