Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257146 | 0.84 | SYK (0.51) | SYKMALT1IDO1PDK2TPSAB1 | |
| SCHEMBL12719469 | 0.79 | ATM (0.53) | SYKATM | |
| SCHEMBL23653517 | 0.77 | LMNA (0.42) | MALT1IDO1L3MBTL1LMNAHPGD | |
| SCHEMBL24702203 | 0.76 | RAB9A (0.40) | MALT1IDO1L3MBTL1LMNAHPGD | |
| SCHEMBL24701949 | 0.76 | RAB9A (0.40) | MALT1IDO1L3MBTL1LMNAHPGD | |
| SCHEMBL30500909 | 0.74 | SYK (0.52) | SYKMALT1ATMALDH1A1 | |
| SCHEMBL12838350 | 0.73 | IDO1 (0.40) | IDO1L3MBTL1LMNAHPGDATM | |
| SCHEMBL24702157 | 0.73 | HDAC3 (0.52) | — | |
| SCHEMBL23435749 | 0.73 | ATM (0.35) | IDO1L3MBTL1LMNAHPGDATM | |
| SCHEMBL24257237 | 0.72 | SYK (0.50) | SYKMALT1TPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036176-A1 | N-CYCLYL-SULFONAMIDES USEFUL FOR INHIBITING RAF | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2022-02-17 | — | — | WO | disclosed |