Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.36 |
| ▸ | TUBB | P07437 | 5/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257577 | 0.79 | TUBB4A (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL24257859 | 0.72 | EGLN1 (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL24257678 | 0.69 | GRM4 (0.50) | RAB9AALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL24257761 | 0.67 | CNR2 (0.40) | HPGDALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL24257758 | 0.67 | POLB (0.41) | RAB9ANPC1ALDH1A1MAPTLMNA | |
| SCHEMBL24257703 | 0.67 | ALDH1A1 (0.37) | HPGDALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL7807352 | 0.67 | TUBB4A (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL26260178 | 0.66 | AGXT (0.39) | HPGDALDH1A1KDM4E | |
| SCHEMBL24257562 | 0.65 | MAOB (0.47) | HPGDALDH1A1HSD17B10MAPTTSHR | |
| SCHEMBL30546831 | 0.65 | MAOB (0.47) | HPGDALDH1A1HSD17B10MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | US | disclosed |
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | US | disclosed |
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | HIF1AN, EGLN3, PHF20 | GRM5 1946/4885TUBB4A 2918/4885TUBB 1604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.