Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 3/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.41 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30453163 | 1.00 | TNK2 (0.47) | TNK2RETMETCCNCCDK8 | |
| SCHEMBL24257696 | 0.89 | TNK2 (0.48) | TNK2RETMETCCNCCDK8 | |
| SCHEMBL24257732 | 0.83 | CCNC (0.49) | TNK2RETMETCCNCCDK8 | |
| SCHEMBL30452665 | 0.83 | CCNC (0.49) | TNK2RETMETCCNCCDK8 | |
| SCHEMBL24257712 | 0.82 | MEN1 (0.48) | TNK2METTTKGPR119 | |
| SCHEMBL30452371 | 0.82 | MEN1 (0.48) | TNK2METTTKGPR119 | |
| SCHEMBL24257541 | 0.82 | IRAK4 (0.44) | RETMET | |
| SCHEMBL27040146 | 0.79 | TNK2 (0.49) | TNK2RETMETCCNCCDK8 | |
| SCHEMBL1653749 | 0.76 | TNK2 (0.56) | TNK2METCCNCCDK8FGFR1 | |
| SCHEMBL24257678 | 0.73 | GRM4 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |