Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30454648 | 0.89 | DHFR (0.44) | LRRK2ADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL24257698 | 0.89 | DHFR (0.44) | LRRK2ADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL30453225 | 0.86 | NPSR1 (0.41) | ADORA1ADORA2ACYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL24257730 | 0.86 | NPSR1 (0.41) | ADORA1ADORA2ACYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL24257700 | 0.84 | BTK (0.54) | LRRK2ADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL30453695 | 0.84 | BTK (0.54) | LRRK2ADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL24257773 | 0.82 | BTK (0.44) | ADORA1ADORA2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30546851 | 0.81 | DHFR (0.43) | ADORA1ADORA2ACYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL24257623 | 0.81 | DHFR (0.43) | ADORA1ADORA2ACYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL24257695 | 0.80 | KDM4E (0.45) | CYP11B1CYP11B2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |