Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257730 | 1.00 | NPSR1 (0.41) | NPSR1KDM4EHPGDRXFP1CHEK1 | |
| SCHEMBL30454648 | 0.86 | DHFR (0.44) | KDM4EHPGDADORA2BADORA1ADORA2A | |
| SCHEMBL24257731 | 0.86 | LRRK2 (0.42) | KDM4EHPGDCYP11B1CYP11B2GABRG2 | |
| SCHEMBL24257698 | 0.86 | DHFR (0.44) | KDM4EHPGDADORA2BADORA1ADORA2A | |
| SCHEMBL24257700 | 0.82 | BTK (0.54) | NPSR1KDM4EHPGDRXFP1ADORA2B | |
| SCHEMBL30453695 | 0.82 | BTK (0.54) | NPSR1KDM4EHPGDRXFP1ADORA2B | |
| SCHEMBL24257773 | 0.80 | BTK (0.44) | NPSR1HPGDADORA1ADORA2AL3MBTL1 | |
| SCHEMBL30546851 | 0.78 | DHFR (0.43) | NPSR1KDM4EHPGDCYP11B1CYP11B2 | |
| SCHEMBL24257623 | 0.78 | DHFR (0.43) | NPSR1KDM4EHPGDCYP11B1CYP11B2 | |
| SCHEMBL24257695 | 0.78 | KDM4E (0.45) | KDM4EHPGDRXFP1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |