Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30452665 | 1.00 | CCNC (0.49) | CCNCCDK8TNK2DDB1CRBN | |
| SCHEMBL30453163 | 0.83 | TNK2 (0.47) | CCNCCDK8TNK2DDB1CRBN | |
| SCHEMBL24257799 | 0.83 | TNK2 (0.47) | CCNCCDK8TNK2DDB1CRBN | |
| SCHEMBL23322341 | 0.79 | MET (0.53) | CCNCCDK8TNK2DDB1CRBN | |
| SCHEMBL24257737 | 0.77 | IRAK4 (0.47) | MET | |
| SCHEMBL22719074 | 0.77 | DDB1 (0.53) | CCNCCDK8DDB1CRBNGPR119 | |
| SCHEMBL658408 | 0.77 | MAP3K7 (0.49) | CCNCCDK8TNK2MAP3K7TAB1 | |
| SCHEMBL17059346 | 0.76 | EGFR (0.53) | CCNCCDK8TNK2DDB1CRBN | |
| SCHEMBL28657129 | 0.76 | DDB1 (0.57) | CCNCCDK8TNK2DDB1CRBN | |
| SCHEMBL29249379 | 0.76 | DDB1 (0.56) | CCNCCDK8TNK2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |