Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30452737 | 0.89 | GRM5 (0.42) | SQORADORA1ADORA2AGABRG2GABRB3 | |
| SCHEMBL24257769 | 0.89 | C5AR1 (0.41) | SQORADORA1ADORA2AGABRG2GABRB3 | |
| SCHEMBL30546869 | 0.89 | C5AR1 (0.41) | SQORADORA1ADORA2AGABRG2GABRB3 | |
| SCHEMBL24257771 | 0.89 | GRM5 (0.42) | SQORADORA1ADORA2AGABRG2GABRB3 | |
| SCHEMBL24257562 | 0.88 | MAOB (0.47) | SQORADORA1ADORA2ACYP1A2CYP3A4 | |
| SCHEMBL30546831 | 0.88 | MAOB (0.47) | SQORADORA1ADORA2ACYP1A2CYP3A4 | |
| SCHEMBL24257522 | 0.88 | SQOR (0.40) | SQORGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL30546879 | 0.85 | HSD17B10 (0.43) | SQORADORA1ADORA2AKDM4EMAPT | |
| SCHEMBL24257819 | 0.85 | HSD17B10 (0.43) | SQORADORA1ADORA2AKDM4EMAPT | |
| SCHEMBL24257578 | 0.84 | CYP11B1 (0.47) | SQORKDM4ECYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |