Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.37 |
| ▸ | VEGFA | P15692 | 4/20 | 0.37 |
| ▸ | FLT1 | P17948 | 4/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257826 | 0.92 | KDM4E (0.41) | GAARAB9AKDM4EHPGDEGLN1 | |
| SCHEMBL26260146 | 0.90 | RAB9A (0.43) | GAARAB9AKDM4EHPGDEGLN1 | |
| SCHEMBL24257801 | 0.82 | RAB9A (0.42) | GAARAB9AKDM4EHPGDEGLN1 | |
| SCHEMBL24257552 | 0.78 | EGLN1 (0.51) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL30454061 | 0.74 | ALDH1A1 (0.43) | GAARAB9AKDM4EHPGDEGLN1 | |
| SCHEMBL26260139 | 0.73 | EGLN1 (0.42) | GAARAB9AHPGDEGLN1VEGFA | |
| SCHEMBL26260138 | 0.73 | SMN1; SMN2 (0.43) | GAARAB9AKDM4EHPGDEGLN1 | |
| SCHEMBL30452640 | 0.72 | EGLN1 (0.46) | KDM4EEGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257548 | 0.72 | EGLN1 (0.46) | KDM4EEGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL26263986 | 0.72 | EGLN1 (0.44) | GAARAB9AHPGDEGLN1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | US | disclosed |
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | US | disclosed |
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | US | disclosed |
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | HIF1AN, EGLN3, PHF20 | GAA 3783/4885RAB9A 739/4885KDM4E 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.