SCHEMBL24257857

SCHEMBL24257857

O=C(O)CCCCCCCCCc1ccc(OCc2ccc(S(=O)(=O)Nc3ncc(C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)O)cn3)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.44
POLB P06746 1/20 0.44
EPOR P19235 5/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
PKM P14618 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
CA2 P00918 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
ITGB3 P05106 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22079977 1.00 TDP1 (0.44) TDP1POLBEPORSMN1; SMN2PKM
SCHEMBL31682051 1.00 TDP1 (0.44) TDP1POLBEPORSMN1; SMN2PKM
SCHEMBL22080442 0.95 SMN1; SMN2 (0.39) TDP1POLBSMN1; SMN2PKMCA2
SCHEMBL24257961 0.95 SMN1; SMN2 (0.39) TDP1POLBSMN1; SMN2PKMCA2
SCHEMBL22079946 0.94 NPC1 (0.40) TDP1SMN1; SMN2PKMHDAC1HDAC6
SCHEMBL24257988 0.94 NPC1 (0.40) TDP1SMN1; SMN2PKMHDAC1HDAC6
SCHEMBL22029401 0.94 NPC1 (0.40) TDP1SMN1; SMN2PKMHDAC1HDAC6
SCHEMBL22080333 0.94 NPC1 (0.40) TDP1SMN1; SMN2PKMHDAC1HDAC6
SCHEMBL31682070 0.94 NPC1 (0.40) TDP1SMN1; SMN2PKMHDAC1HDAC6
SCHEMBL22080331 0.94 TDP1 (0.38) TDP1POLBSMN1; SMN2PKMHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3893934-B1 INSULIN CONJUGATES SANOFI SA (FR) 2025-09-10 EP disclosed
US-20220048968-A1 INSULIN CONJUGATES SANOFI (FR) 2022-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220048968-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R TDP1 4783/4885POLB 4107/4885EPOR 1577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.