Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17501181 | 0.85 | RORC (0.34) | RORCGRIN2B | |
| SCHEMBL24258253 | 0.78 | GRIN2B (0.36) | GRIN2BCYP2D6KCNH2 | |
| SCHEMBL24258278 | 0.78 | GRIN2B (0.35) | RORCGRIN2BCYP2D6KCNH2 | |
| SCHEMBL23545651 | 0.76 | IRAK4 (0.37) | RORCGRIN2BCYP2D6KCNH2 | |
| SCHEMBL24258279 | 0.76 | CACNA1B (0.33) | RORCGRIN2B | |
| SCHEMBL25436999 | 0.76 | SLC6A2 (0.37) | RORCGRIN2BCYP2D6KCNH2 | |
| SCHEMBL19640409 | 0.76 | CSF1R (0.36) | RORC | |
| SCHEMBL19640732 | 0.76 | RORC (0.34) | RORCGRIN2BCYP2D6KCNH2 | |
| SCHEMBL17501483 | 0.75 | CYP11B2 (0.39) | RORCCYP2D6 | |
| SCHEMBL19640536 | 0.75 | RORC (0.35) | RORCKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |