Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10073807 | 0.83 | MEN1 (0.69) | MEN1RAB9AKMT2AHRH3POLB | |
| SCHEMBL16980401 | 0.81 | RAB9A (0.53) | MEN1RAB9AKMT2AHRH3POLB | |
| SCHEMBL1239998 | 0.78 | BCHE (0.61) | MEN1RAB9AKMT2AHRH3POLB | |
| SCHEMBL23545659 | 0.77 | HRH3 (0.50) | MEN1RAB9AKMT2AHRH3POLB | |
| SCHEMBL16980536 | 0.74 | POLB (0.59) | MEN1RAB9AKMT2AHRH3POLB | |
| SCHEMBL14850003 | 0.74 | SMN1; SMN2 (0.49) | MEN1RAB9AKMT2AHRH3POLB | |
| SCHEMBL19650838 | 0.74 | MEN1 (0.42) | MEN1RAB9AKMT2AHRH3POLB | |
| SCHEMBL24468257 | 0.74 | CXCR4 (0.39) | GRIN2BHDAC1 | |
| SCHEMBL3236686 | 0.74 | POLB (0.81) | MEN1RAB9AKMT2AHRH3POLB | |
| SCHEMBL2731922 | 0.74 | ACHE (0.61) | MEN1RAB9AKMT2AHRH3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |