Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | RRM2 | P31350 | 1/20 | 0.35 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9908277 | 0.81 | L3MBTL1 (0.43) | HRH3CYP11B1CYP11B2 | |
| SCHEMBL25813170 | 0.80 | PIK3CD (0.44) | LOXL2HRH3ADRB2RRM2 | |
| SCHEMBL29594784 | 0.79 | POLB (0.36) | CYP11B1CYP11B2 | |
| SCHEMBL246217 | 0.79 | POLB (0.36) | CYP11B1CYP11B2 | |
| SCHEMBL247901 | 0.79 | KMT2A (0.36) | CYP11B1CYP11B2 | |
| SCHEMBL507633 | 0.79 | AOC3 (0.41) | LOXL2HRH3ADRB2RRM2ABAT | |
| Hydrochloric Acid SCHEMBL10483859 | 0.78 | KMT2A (0.35) | CYP11B1CYP11B2 | |
| SCHEMBL10483985 | 0.77 | MC4R (0.41) | HRH3 | |
| SCHEMBL14903596 | 0.76 | ESR1 (0.41) | CYP11B1CYP11B2 | |
| SCHEMBL19438349 | 0.76 | ALDH1A1 (0.32) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |