Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27704317 | 0.90 | PRMT5 (0.47) | KMT2AMEN1SMN1; SMN2POLBHRH3 | |
| SCHEMBL2635104 | 0.88 | POLB (0.50) | KMT2AMEN1SMN1; SMN2POLBRAB9A | |
| SCHEMBL3081029 | 0.83 | HTR1A (0.43) | KMT2AMEN1SMN1; SMN2POLBRAB9A | |
| SCHEMBL3093702 | 0.83 | SLC6A4 (0.43) | KMT2AMEN1SMN1; SMN2POLBRAB9A | |
| SCHEMBL10186620 | 0.81 | POLB (0.41) | KMT2AMEN1SMN1; SMN2POLBRAB9A | |
| SCHEMBL16033868 | 0.81 | POLB (0.53) | KMT2AMEN1POLBRAB9AHRH3 | |
| SCHEMBL1750833 | 0.81 | P2RX7 (0.44) | KMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL1750883 | 0.80 | TSHR (0.44) | KMT2ASMN1; SMN2POLBRAB9AHRH3 | |
| Hydrochloric Acid SCHEMBL18130662 | 0.80 | POLB (0.56) | KMT2AMEN1POLBRAB9AHRH3 | |
| SCHEMBL10186616 | 0.79 | SPHK1 (0.40) | KMT2AMEN1SMN1; SMN2POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |