Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19650787 | 0.85 | TSPO (0.56) | TSPOPOLBTSHRKMT2AMEN1 | |
| SCHEMBL17526005 | 0.76 | TSPO (0.41) | TSPOPOLBTSHRKMT2AMEN1 | |
| SCHEMBL19655675 | 0.72 | TSPO (0.43) | TSPOPOLBTSHRKMT2AMEN1 | |
| SCHEMBL7776521 | 0.71 | POLB (0.71) | POLBTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL20259846 | 0.65 | NPC1 (0.36) | TSPOPOLBALDH1A1TRPM8 | |
| SCHEMBL27741606 | 0.64 | TSPO (0.55) | TSPOPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL23121606 | 0.64 | TSPO (0.50) | TSPOPOLBTSHRKMT2AMEN1 | |
| SCHEMBL5694553 | 0.64 | TSPO (0.72) | TSPOTSHRALDH1A1TRPM8SMN1; SMN2 | |
| SCHEMBL23121611 | 0.64 | TSPO (0.50) | TSPOPOLBTSHRKMT2AMEN1 | |
| SCHEMBL11425364 | 0.63 | MEN1 (0.51) | TSPOPOLBTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |