Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19650787 | 0.82 | TSPO (0.56) | TSPOKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL24258421 | 0.76 | TSPO (0.43) | TSPOKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL19655675 | 0.70 | TSPO (0.43) | TSPOKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL7776521 | 0.66 | POLB (0.71) | KMT2AMEN1L3MBTL1POLBTSHR | |
| SCHEMBL19187746 | 0.65 | CES2 (0.38) | KMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL18536172 | 0.64 | CES2 (0.39) | KMT2AMEN1L3MBTL1TSHRKDM4E | |
| SCHEMBL27741606 | 0.62 | TSPO (0.55) | TSPOKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL23121606 | 0.62 | TSPO (0.50) | TSPOKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL5694553 | 0.62 | TSPO (0.72) | TSPOTSHRLTB4R2CRHBPCRHR2 | |
| SCHEMBL23121611 | 0.62 | TSPO (0.50) | TSPOKMT2AMEN1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016020288-A1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION A/S (DK) | 2016-02-11 | — | — | WO | disclosed |