Sugi Predict

Sugi Predict / Compounds / SCHEMBL2425847

SCHEMBL2425847

SCHEMBL2425847

O=[N+]([O-])c1cc2ccccc2nc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.58
▸ ATM Q13315 1/20 0.58
▸ MAPT P10636 7/20 0.54
▸ ALDH1A1 P00352 5/20 0.54
▸ TDP1 Q9NUW8 4/20 0.54
▸ RAB9A P51151 3/20 0.54
▸ NPC1 O15118 2/20 0.54
▸ NPSR1 Q6W5P4 1/20 0.54
▸ KMT2A Q03164 4/20 0.54
▸ MEN1 O00255 2/20 0.54
▸ HPRT1 P00492 1/20 0.45
▸ CASP6 P55212 1/20 0.45
▸ GLA P06280 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ ACHE P22303 1/20 0.43
▸ PIN1 Q13526 2/20 0.43
▸ TSHR P16473 1/20 0.42
▸ L3MBTL1 Q9Y468 2/20 0.41
▸ LMNA P02545 1/20 0.41
▸ MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14661558 0.82 RAB9A (0.54) HTTATMMAPTALDH1A1TDP1
SCHEMBL5793924 0.81 MAPK1 (0.50) HTTATMMAPTALDH1A1TDP1
SCHEMBL1682777 0.80 RAB9A (0.55) HTTATMMAPTALDH1A1TDP1
SCHEMBL9120430 0.80 RAB9A (0.55) HTTATMMAPTALDH1A1TDP1
Acridine SCHEMBL27545385 0.79 RAB9A (0.63) HTTATMMAPTALDH1A1TDP1
SCHEMBL28818163 0.79 RAB9A (0.54) HTTATMMAPTALDH1A1TDP1
SCHEMBL11108095 0.79 RAB9A (0.54) HTTATMMAPTALDH1A1TDP1
SCHEMBL2011678 0.79 RAB9A (0.54) HTTATMMAPTALDH1A1TDP1
SCHEMBL358410 0.79 RAB9A (0.58) HTTATMMAPTALDH1A1TDP1
SCHEMBL27916543 0.79 RAB9A (0.54) HTTATMMAPTALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108178247-A The graphite electrode modified based on CrO-FeO-PbO and quinoline 光合强化（北京）生物科技有限公司 2018-06-19 — — CN claimed
CN-108003153-A Nitrogenous five-ring heterocycles and quinolines and its salt, preparation method, pharmaceutical composition and purposes 中国医学科学院肿瘤医院 2018-05-08 — — CN claimed
CN-101932579-A Novel imidazo-heteroaryl derivatives with antibacterial properties MUTABILIS SA 2010-12-29 — — CN claimed
US-20250171431-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE HORIZON THERAPEUTICS IRELAND DAC (IE) 2025-05-29 — — US disclosed
US-20250090540-A1 PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. 2025-03-20 — — US disclosed
WO-2025030163-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE HORIZON THERAPEUTICS IRELAND DAC (IE) 2025-02-06 — — WO disclosed
EP-4399196-A1 PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF Relay Therapeutics, Inc. (US) 2024-07-17 — — EP disclosed
CN-118201896-A PI 3K-alpha inhibitors and methods of use thereof 传达治疗有限公司 2024-06-14 — — CN disclosed
WO-2024074611-A1 PRMT5 INHIBITORS Ryvu Therapeutics S.A. (PL) 2024-04-11 — — WO disclosed
WO-2023039532-A1 PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. (US) 2023-03-16 — — WO disclosed
CN-114269346-A Compounds and methods for treating and preventing fibrotic disease states and cancer 普渡研究基金会 2022-04-01 — — CN disclosed
WO-1993005042-A1 1-SUBSTITUTED 1H-IMIDAZO(4,5-C)QUINOLIN-4-AMINES; INTERMEDIATE AND PHARMACEUTICAL COMPOSITIONS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-03-18 — — WO disclosed
US-5008263-A Platelet activating factor antagonists; antiallergens; antiinflammatory agents PFIZER INC. (US) 1991-04-16 — — US disclosed
CN-1045783-A Diaza  class anti-allergy medicament PFIZER (US) 1990-10-03 — — CN disclosed
EP-0389189-A2 Diazepine antiallergy agents Pfizer Limited (GB) 1990-09-26 — — EP disclosed
EP-0029319-B1 QUINOLINYLOXY(AMINO)PHENOXYALKANE CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR SYNTHESIS, HERBICIDAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS HERBICIDES ICI AUSTRALIA LIMITED (AU) 1986-01-15 — — EP disclosed
US-4444584-A Ethyl 2[4-(7-chloroquinolin-3-yloxy)phenoxy]propionate, the N-oxide, and herbicidal compositions and methods employing them ICI AUSTRALIA LIMITED (AU) 1984-04-24 — — US disclosed
EP-0098751-A2 Quinolinyloxy(amino)phenols and alkoxyphenyloxy(amino)quinolines ICI AUSTRALIA LIMITED (AU) 1984-01-18 — — EP disclosed
EP-0029319-A2 Quinolinyloxy(amino)phenoxyalkane carboxylic acid derivatives, process for their synthesis, herbicidal compositions containing them and their use as herbicides ICI AUSTRALIA LIMITED (AU) 1981-05-27 — — EP disclosed
US-4025510-A DYES FOR POLYESTERS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-05-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250171431-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE IGF1R, TRHR, TSHR HTT 163/4885ATM 980/4885MAPT 3496/4885
US-20250090540-A1 PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF PIK3CA, PIK3CB, PIK3CD HTT 2866/4885ATM 449/4885MAPT 3881/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.