Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 20/20 | 0.62 |
| ▸ | BRD4 | O60885 | 6/20 | 0.61 |
| ▸ | EP300 | Q09472 | 2/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24258507 | 0.92 | CREBBP (0.60) | CREBBPBRD4EP300 | |
| SCHEMBL24258490 | 0.79 | CREBBP (0.43) | CREBBPBRD4 | |
| SCHEMBL19643782 | 0.76 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL30117226 | 0.76 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL19644157 | 0.76 | CREBBP (1.00) | CREBBPBRD4EP300BRPF1 | |
| SCHEMBL19657623 | 0.76 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL19657918 | 0.75 | CREBBP (0.42) | CREBBPBRD4EP300 | |
| SCHEMBL19657389 | 0.70 | CREBBP (0.40) | CREBBPBRD4EP300 | |
| SCHEMBL21255156 | 0.70 | CREBBP (0.41) | CREBBPBRD4EP300 | |
| SCHEMBL19657663 | 0.70 | CREBBP (0.43) | CREBBPBRD4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |