Sugi Predict

Sugi Predict / Compounds / SCHEMBL242591

SCHEMBL242591

SCHEMBL242591

COC(=O)c1cccnc1CCl

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.51
▸ L3MBTL1 Q9Y468 2/20 0.50
▸ PKM P14618 1/20 0.50
▸ MAP2K1 Q02750 1/20 0.49
▸ KDM4E B2RXH2 6/20 0.48
▸ POLB P06746 3/20 0.46
▸ ATM Q13315 1/20 0.46
▸ ALDH1A1 P00352 5/20 0.45
▸ MAPT P10636 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ TSHR P16473 2/20 0.44
▸ LMNA P02545 2/20 0.44
▸ HSD17B10 Q99714 2/20 0.44
▸ ALOX15 P16050 1/20 0.44
▸ CNR2 P34972 1/20 0.44
▸ CFTR P13569 1/20 0.43
▸ MAPK10 P53779 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29363643 1.00 TDP1 (0.51) TDP1L3MBTL1PKMMAP2K1KDM4E
SCHEMBL6017355 0.86 TDP1 (0.54) TDP1L3MBTL1PKMMAP2K1KDM4E
SCHEMBL29361610 0.85 TDP1 (0.53) TDP1L3MBTL1PKMMAP2K1KDM4E
SCHEMBL30798461 0.85 TDP1 (0.53) TDP1L3MBTL1PKMMAP2K1KDM4E
SCHEMBL4556786 0.85 TDP1 (0.53) TDP1L3MBTL1PKMMAP2K1KDM4E
SCHEMBL4074618 0.85 TDP1 (0.53) TDP1L3MBTL1PKMMAP2K1KDM4E
SCHEMBL4034951 0.84 TSHR (0.56) L3MBTL1KDM4EPOLBATMALDH1A1
SCHEMBL22912507 0.83 TDP1 (0.51) TDP1L3MBTL1PKMMAP2K1KDM4E
SCHEMBL16790454 0.83 TDP1 (0.51) TDP1L3MBTL1PKMMAP2K1KDM4E
SCHEMBL21957938 0.82 TDP1 (0.50) TDP1L3MBTL1PKMMAP2K1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 172 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022166440-A1 METHOD FOR PREPARING MOXIFLOXACIN INTERMEDIATE, (S,S)-2,8-DIAZABICYCLO[4,3,0]NONANE 台州市生物医化产业研究院有限公司 2022-08-11 — — WO claimed
CN-112939847-B Method for preparing moxifloxacin intermediate (S, S) -2, 8-diazabicyclo [4,3,0] nonane 台州市生物医化产业研究院有限公司 2022-05-13 — — CN claimed
CN-113943248-B Acetamiprid hapten, acetamiprid complete antigen, and synthesis and application thereof 信达安检测技术(天津)有限公司 2022-03-08 — — CN claimed
CN-112939847-A Method for preparing moxifloxacin intermediate (S, S) -2, 8-diazabicyclo [4,3,0] nonane 台州市生物医化产业研究院有限公司 2021-06-11 — — CN claimed
US-20260138978-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 VANDERBILT UNIV (US) 2026-05-21 — — US disclosed
US-12448368-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2025-10-21 — — US disclosed
US-20250122176-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2025-04-17 — — US disclosed
US-20250092021-A9 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2025-03-20 — — US disclosed
EP-3398947-B1 NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUND, AS WELL AS PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN) 2024-08-28 — — EP disclosed
WO-2024086570-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 VANDERBILT UNIVERSITY (US) 2024-04-25 — — WO disclosed
WO-2024086569-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 VANDERBILT UNIVERSITY (US) 2024-04-25 — — WO disclosed
CN-117321051-A Compounds as PARP inhibitors 重庆复尚源创医药技术有限公司 2023-12-29 — — CN disclosed
WO-2002083685-A1 CYCLOHEXYLPHENYL VASOPRESSIN AGONISTS WYETH (US) 2002-10-24 — — WO disclosed
WO-2002083683-A1 NOVEL TRICYCLIC PYRIDYL BENZAZEPINE CARBOXAMIDES AND DERIVATIVES THEREOF TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS WYETH (US) 2002-10-24 — — WO disclosed
WO-2002083678-A1 TRICYCLIC DIAZEPINES AS TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS WYETH (US) 2002-10-24 — — WO disclosed
WO-2002083680-A1 NOVEL TRICYCLIC HYDROXY CARBOXAMIDES AND DERIVATIVES THEREOF TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS WYETH (US) 2002-10-24 — — WO disclosed
WO-2002083145-A1 N-BIPHENYLCARBONYL- AND N-PHENYLPYRIDYLCARBONYL SUBSTITUTED BI- AND TRICYCLIC AZEPINES AND DIAZEPINES AS VASOPRESSING AGONISTS WYETH (US) 2002-10-24 — — WO disclosed
US-5763437-A Benzodiazepine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-09 — — US disclosed
EP-0804425-A2 BENZODIAZEPINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-05 — — EP disclosed
WO-1996004254-A2 BENZODIAZEPINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-02-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122176-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 TDP1 1621/4885L3MBTL1 3975/4885PKM 1672/4885
US-20250092021-A9 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 TDP1 1621/4885L3MBTL1 3975/4885PKM 1672/4885
US-12448368-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 TDP1 1371/4885L3MBTL1 3847/4885PKM 1534/4885
US-20260138978-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 CHRM1, CHRM4, CHRM2 TDP1 2179/4885L3MBTL1 1685/4885PKM 1705/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.