Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | CETP | P11597 | 1/20 | 0.62 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20761408 | 0.92 | MDM4 (0.77) | MDM4TP53TSHRCETPMDM2 | |
| SCHEMBL14790209 | 0.87 | TP53 (0.56) | MDM4TP53TSHRCETPMDM2 | |
| SCHEMBL6689158 | 0.85 | ALDH1A1 (0.74) | TSHRALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL24071131 | 0.84 | MDM4 (0.67) | MDM4TP53TSHRCETPMDM2 | |
| SCHEMBL10459409 | 0.81 | ALDH1A1 (0.53) | MDM4TP53TSHRALDH1A1HPGD | |
| SCHEMBL14017837 | 0.80 | ALDH1A1 (0.57) | TSHRALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL12841231 | 0.80 | MDM4 (1.00) | MDM4TP53CETPMDM2L3MBTL1 | |
| SCHEMBL5186841 | 0.80 | MDM4 (0.67) | MDM4TP53CETPMDM2L3MBTL1 | |
| SCHEMBL10447471 | 0.80 | TP53 (0.67) | MDM4TP53CETPMDM2L3MBTL1 | |
| SCHEMBL6264293 | 0.79 | MAPT (0.69) | MDM4TP53CETPMDM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668872-B1 | 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS IMMUNOSTIMULANT TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2022-02-23 | — | — | EP | disclosed |