Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24263403 | 0.90 | TYK2 (0.48) | TYK2PDE4DMAPTSMN1; SMN2USP2 | |
| SCHEMBL20504574 | 0.89 | IDO1 (0.37) | TYK2PDE4DMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL20557221 | 0.89 | MAPT (0.39) | MAPTNPSR1LMNAPOLBL3MBTL1 | |
| SCHEMBL16794637 | 0.88 | TYK2 (0.45) | TYK2PDE4DMAPTNPSR1POLB | |
| SCHEMBL20557551 | 0.87 | TYK2 (0.45) | TYK2PDE4DMAPTNPSR1POLB | |
| SCHEMBL24263290 | 0.87 | GAA (0.37) | TYK2PDE4DMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL24263282 | 0.85 | TYK2 (0.52) | TYK2JAK1 | |
| SCHEMBL31245741 | 0.85 | TYK2 (0.52) | TYK2JAK1 | |
| SCHEMBL16794711 | 0.84 | TYK2 (0.39) | TYK2MAPTNPSR1TP53ADORA3 | |
| SCHEMBL31245746 | 0.84 | TYK2 (0.41) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022037694-A1 | A CLASS OF FIVE- AND SIX-MEMBERED HETEROCYCLIC COMPOUNDS AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITORS | 轶诺(浙江)药业有限公司 | 2022-02-24 | — | — | WO | disclosed |