Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24263413 | 0.92 | TYK2 (0.41) | TYK2PDE4DMAPTTAS2R14TP53 | |
| SCHEMBL24263379 | 0.90 | TYK2 (0.46) | TYK2PDE4DMAPTLMNAALDH1A1 | |
| SCHEMBL20504588 | 0.88 | TYK2 (0.39) | TYK2PDE4DZAP70KARS1LMNA | |
| SCHEMBL16794686 | 0.87 | TYK2 (0.47) | TYK2PDE4D | |
| SCHEMBL24263509 | 0.86 | GPR6 (0.35) | TYK2PDE4DZAP70KARS1KDM4E | |
| SCHEMBL31245725 | 0.84 | TYK2 (0.55) | TYK2JAK2JAK1 | |
| SCHEMBL24263286 | 0.84 | TYK2 (0.55) | TYK2JAK2JAK1 | |
| SCHEMBL31245711 | 0.83 | TYK2 (0.43) | TYK2PDE4D | |
| SCHEMBL16794699 | 0.82 | TYK2 (0.41) | TYK2PDE4DMAPTALDH1A1KDM4E | |
| SCHEMBL31245693 | 0.82 | TYK2 (0.39) | TYK2PDE4DTAS2R14HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022037694-A1 | A CLASS OF FIVE- AND SIX-MEMBERED HETEROCYCLIC COMPOUNDS AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITORS | 轶诺(浙江)药业有限公司 | 2022-02-24 | — | — | WO | disclosed |