SCHEMBL242636

SCHEMBL242636

NS(=O)(=O)c1cccc(NC(=O)Oc2ccccc2)c1

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA1 P00915 9/20 0.67
CA2 P00918 9/20 0.67
CA9 Q16790 6/20 0.67
CA12 O43570 4/20 0.67
MAPT P10636 3/20 0.67
KMT2A Q03164 2/20 0.63
MEN1 O00255 1/20 0.63
CYP1A2 P05177 1/20 0.59
KDM4E B2RXH2 1/20 0.55
ALDH1A1 P00352 1/20 0.55
CA4 P22748 1/20 0.54
POLB P06746 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20389248 0.87 CYP1A2 (0.61) CA1CA2CA9CA12MAPT
SCHEMBL1893008 0.86 CYP1A2 (0.63) MAPTKMT2AMEN1CYP1A2KDM4E
SCHEMBL15899956 0.84 CA1 (0.54) CA1CA2CA9CA12MAPT
SCHEMBL241662 0.84 CA2 (0.67) CA1CA2CA9CA12MAPT
SCHEMBL28672560 0.84 CA1 (0.64) CA1CA2CA9CA12MAPT
SCHEMBL8535425 0.83 CA2 (0.65) CA1CA2CA9CA12MAPT
SCHEMBL8048626 0.83 CYP1A2 (0.76) MAPTKMT2AMEN1CYP1A2KDM4E
SCHEMBL29673499 0.82 CYP1A2 (0.58) MAPTKMT2ACYP1A2KDM4EALDH1A1
SCHEMBL1395590 0.80 CA1 (1.00) CA1CA2CA9CA12MAPT
SCHEMBL27747721 0.80 CA1 (0.76) CA1CA2CA9CA12MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4334298-B1 UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER SCORPION THERAPEUTICS INC (US) 2026-02-18 EP disclosed
US-20250250259-A1 METHODS FOR TREATING CANCER SCORPION THERAPEUTICS, INC. 2025-08-07 US disclosed
US-12312341-B2 Methods for treating cancer SCORPION THERAPEUTICS, INC. (US) 2025-05-27 US disclosed
US-20240400543-A1 METHODS FOR TREATING CANCER SCORPION THERAPEUTICS, INC. 2024-12-05 US disclosed
US-20240300939-A1 UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER SCORPION THERAPEUTICS, INC. 2024-09-12 US disclosed
US-12084434-B2 Methods for treating cancer SCORPION THERAPEUTICS, INC. (US) 2024-09-10 US disclosed
EP-4334298-A1 UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER Scorpion Therapeutics, Inc. (US) 2024-03-13 EP disclosed
US-20240076289-A1 METHODS FOR TREATING CANCER SCORPION THERAPEUTICS, INC. 2024-03-07 US disclosed
US-11897871-B1 Methods for treating cancer SCORPION THERAPEUTICS, INC. (US) 2024-02-13 US disclosed
WO-2022265993-A1 UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER SCORPION THERAPEUTICS, INC. (US) 2022-12-22 WO disclosed
EP-1889846-A1 Purine derivatives as A2a agonists Novartis AG (CH) 2008-02-20 EP disclosed
WO-2008006563-A1 PURINE DERIVATIVES AS A2A AGONISTS NOVARTIS AG (CH) 2008-01-17 WO disclosed
WO-2007121920-A2 PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS NOVARTIS AG (CH) 2007-11-01 WO disclosed
US-7288537-B2 Azetidine derivatives as CCR-3 receptor antagonists NOVARTIS AG (CH) 2007-10-30 US disclosed
US-20050222118-A1 Azetidine derivatives as ccr-3 receptor antagonists NOVARTIS AG (CH) 2005-10-06 US disclosed
EP-1487435-A1 AZETIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS Novartis AG (CH) 2004-12-22 EP disclosed
WO-2003077907-A1 AZETIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS NOVARTIS AG (CH) 2003-09-25 WO disclosed
US-5215570-A Plant safening agents CIBA-GEIGY CORPORATION (US) 1993-06-01 US disclosed
EP-0365484-B1 SULFAMOYL PHENYL UREAS CIBA-GEIGY AG (CH) 1993-01-07 EP disclosed
EP-0365484-A1 Sulfamoyl phenyl ureas CIBA-GEIGY AG (CH) 1990-04-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240300939-A1 UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER PIK3CA, PIK3CG, PIK3CD CA1 3519/4885CA2 2860/4885CA9 2171/4885
US-20050222118-A1 Azetidine derivatives as ccr-3 receptor antagonists CCR3, CCR1, CCR9 CA1 3444/4885CA2 1584/4885CA9 1242/4885
US-11897871-B1 Methods for treating cancer PIK3CA, PTEN, BRCA1 CA1 2709/4885CA2 1409/4885CA9 1355/4885
US-12312341-B2 Methods for treating cancer PIK3CA, PTEN, BRCA1 CA1 2709/4885CA2 1409/4885CA9 1355/4885
US-20240076289-A1 METHODS FOR TREATING CANCER PIK3CA, PTEN, BRCA1 CA1 2709/4885CA2 1409/4885CA9 1355/4885
US-20250250259-A1 METHODS FOR TREATING CANCER PIK3CA, PTEN, BRCA1 CA1 2709/4885CA2 1409/4885CA9 1355/4885
US-20240400543-A1 METHODS FOR TREATING CANCER PIK3CA, PTEN, BRCA1 CA1 2709/4885CA2 1409/4885CA9 1355/4885
US-12084434-B2 Methods for treating cancer PIK3CA, PTEN, BRCA1 CA1 2709/4885CA2 1409/4885CA9 1355/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.