SCHEMBL24264683

SCHEMBL24264683

Cc1cc(C=O)cc(F)c1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.39
SRC P12931 1/20 0.37
ALDH1A1 P00352 2/20 0.32
ALDH1A3 P47895 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CYP2A6 P11509 1/20 0.31
TUBB1 Q9H4B7 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9712685 0.88 SRC (0.41) KIF11SRCALDH1A1ALDH1A3CYP2A6
SCHEMBL26760559 0.86 KIF11 (0.44) KIF11ALDH1A1SMN1; SMN2
SCHEMBL19449779 0.77 SRC (0.34) KIF11SRC
SCHEMBL19125728 0.75 SRC (0.41) KIF11SRCALDH1A1ALDH1A3SMN1; SMN2
SCHEMBL29950733 0.75 SRC (0.41) KIF11SRCALDH1A1ALDH1A3SMN1; SMN2
SCHEMBL12594000 0.75 TUBB1 (0.42) KIF11SRCALDH1A1ALDH1A3SMN1; SMN2
SCHEMBL19449780 0.73 SRC (0.32) SRC
SCHEMBL13550033 0.73 RAPGEF4 (0.38)
SCHEMBL13550144 0.73 RAPGEF4 (0.38)
SCHEMBL13550132 0.73 RAPGEF4 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022040607-A1 SMALL MOLECULE ALBUMIN BINDERS OREGON HEALTH & SCIENCE UNIVERSITY (US) 2022-02-24 WO disclosed