Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.58 |
| ▸ | PRKDC | P78527 | 10/20 | 0.58 |
| ▸ | MTOR | P42345 | 11/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.55 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.55 |
| ▸ | NEK2 | P51955 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29492863 | 1.00 | PIK3CA (0.58) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL29492846 | 0.90 | PIK3CA (0.62) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270535 | 0.90 | PIK3CA (0.62) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270662 | 0.85 | PIK3CA (0.44) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL928021 | 0.78 | MTOR (0.87) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL28875487 | 0.76 | MTOR (0.48) | MTOR | |
| SCHEMBL24270530 | 0.75 | PIK3CA (0.78) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL29492843 | 0.75 | PIK3CA (0.78) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270543 | 0.74 | PIK3CA (0.47) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270867 | 0.74 | PRKDC (0.70) | PIK3CAPRKDCMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365559-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | AUCKLAND UNISERVICES LIMITED (NZ) | 2023-11-16 | — | — | US | disclosed |
| WO-2022064430-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | AUCKLAND UNISERVICES LIMITED (NZ) | 2022-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365559-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | DCK, DTYMK, TYMP | PIK3CA 302/4885PRKDC 64/4885MTOR 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.