Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 15/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17643312 | 0.86 | GRIN2B (0.64) | GRIN2BGRIN1 | |
| SCHEMBL26019872 | 0.86 | GRIN2B (0.64) | GRIN2BGRIN1 | |
| SCHEMBL20090988 | 0.86 | GRIN2B (0.64) | GRIN2BGRIN1 | |
| SCHEMBL22239247 | 0.82 | GRIN2B (0.47) | GRIN2BGRIN1 | |
| SCHEMBL22239248 | 0.81 | GRIN2B (0.48) | GRIN2BGRIN1 | |
| SCHEMBL22239240 | 0.79 | GRIN2B (0.50) | GRIN2BGRIN1 | |
| SCHEMBL4936082 | 0.78 | MEN1 (0.75) | MEN1KMT2AALDH1A1LMNANPC1 | |
| SCHEMBL13777920 | 0.78 | MEN1 (0.56) | MEN1KMT2AGRIN2BALDH1A1NPC1 | |
| SCHEMBL6397229 | 0.77 | KMT2A (0.59) | MEN1KMT2AGRIN2BALDH1A1LMNA | |
| SCHEMBL7207451 | 0.76 | KMT2A (0.57) | MEN1KMT2AGRIN2BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4282412-A2 | N-ALKYLARYL-5-OXYHETEROARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | Novartis AG (CH) | 2023-11-29 | — | — | EP | disclosed |
| EP-3974420-A1 | N-ALKYLARYL-5-OXYHETEROARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | Cadent Therapeutics, Inc. (US) | 2022-03-30 | — | — | EP | disclosed |