Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15741283 | 0.78 | ALDH1A1 (0.48) | PIK3CAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9611707 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDHSD17B10CDK2 | |
| SCHEMBL7965088 | 0.76 | CDK2 (0.54) | PIK3CAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL14682567 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHSD17B10CDK2 | |
| SCHEMBL947308 | 0.74 | CDK2 (0.55) | ALDH1A1KDM4EHPGDHSD17B10CDK2 | |
| SCHEMBL8311759 | 0.73 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDHSD17B10CDK2 | |
| SCHEMBL15742556 | 0.72 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDHSD17B10CDK2 | |
| SCHEMBL15004608 | 0.72 | KMT2A (0.61) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL4052458 | 0.72 | CDK2 (0.50) | ALDH1A1KDM4EHPGDHSD17B10CDK2 | |
| SCHEMBL15004600 | 0.71 | NPC1 (0.58) | ALDH1A1KDM4EHPGDHSD17B10CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220064150-A1 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS | PTC THERAPEUTICS INC (US) | 2022-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064150-A1 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS | BMI1, BRPF3, BAZ2A | PIK3CA 2127/4885ALDH1A1 1803/4885KDM4E 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.