Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.50 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | USP7 | Q93009 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15557657 | 0.76 | KDM4E (0.51) | ALDH1A1KDM4EGAAHPGDPOLB | |
| SCHEMBL24276363 | 0.72 | PIK3CA (0.49) | CDK2CDK4ALDH1A1KDM4EGAA | |
| SCHEMBL18100956 | 0.71 | CDK2 (0.51) | CDK2CDK4ALDH1A1KDM4EGAA | |
| SCHEMBL9611707 | 0.70 | ALDH1A1 (0.56) | CDK2CDK4ALDH1A1KDM4EGAA | |
| SCHEMBL15004600 | 0.69 | NPC1 (0.58) | CDK2CDK4ALDH1A1KDM4EGAA | |
| SCHEMBL16563652 | 0.69 | KMT2A (0.54) | CDK2CDK4ALDH1A1KDM4EGAA | |
| SCHEMBL18100935 | 0.69 | CDK2 (0.58) | CDK2CDK4ALDH1A1KDM4EGAA | |
| SCHEMBL7965088 | 0.69 | CDK2 (0.54) | CDK2CDK4ALDH1A1KDM4EGAA | |
| SCHEMBL18100955 | 0.68 | CDK2 (0.57) | CDK2CDK4ALDH1A1KDM4EGAA | |
| SCHEMBL15741283 | 0.68 | ALDH1A1 (0.48) | CDK2CDK4ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079747-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS ANABOLIC AGENTS FOR LIVESTOCK ANIMALS | Pfizer Limited (GB) | 2009-07-22 | — | — | EP | disclosed |
| WO-2009030952-A2 | PHENYLCARBOXAMIDE DERIVATIVES AS INHIBITORS AND EFFECTORS OF THE HEDGEHOG PATHWAY | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | WO | disclosed |
| WO-2008044127-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS ANABOLIC AGENTS FOR LIVESTOCK ANIMALS | PFIZER LIMITED (GB) | 2008-04-17 | — | — | WO | disclosed |