Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.46 |
| ▸ | PIM1 | P11309 | 6/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.46 |
| ▸ | ATR | Q13535 | 3/20 | 0.42 |
| ▸ | SLC9A5 | Q14940 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2429159 | 0.99 | GRM5 (0.55) | GRM5PIM2PIM1PIM3ATR | |
| SCHEMBL12288569 | 0.94 | GRM5 (0.59) | GRM5PIM2PIM1PIM3ATR | |
| SCHEMBL12288563 | 0.93 | GRM5 (0.61) | GRM5PIM2PIM1PIM3ATR | |
| Trifluoroacetic Acid SCHEMBL2436371 | 0.92 | GRM5 (0.45) | GRM5PIM2PIM1PIM3ATR | |
| SCHEMBL12288567 | 0.86 | GRM5 (0.49) | GRM5PIM2PIM1PIM3ATR | |
| Trifluoroacetic Acid SCHEMBL2432535 | 0.79 | ATR (0.42) | GRM5ATRPLAUALDH1A1TP53 | |
| Trifluoroacetic Acid SCHEMBL2434092 | 0.79 | HDAC6 (0.50) | GRM5PIM2PIM1PIM3ATR | |
| Trifluoroacetic Acid SCHEMBL2432097 | 0.78 | HDAC6 (0.49) | GRM5PIM2PIM1PIM3ATR | |
| Trifluoroacetic Acid SCHEMBL2432623 | 0.77 | HDAC6 (0.51) | GRM5PIM2PIM1PIM3ATR | |
| Trifluoroacetic Acid SCHEMBL2434892 | 0.76 | PLAU (0.53) | GRM5ATRPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110217265-A1 | Screening for Inhibitors of HCV Amphipathic Helix (AH) Function | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-08 | — | — | US | claimed |
| WO-2010039195-A2 | SCREENING FOR INHIBITORS OF HCV AMPHIPATHIC HELIX (AH) FUNCTION | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2010-04-08 | — | — | WO | claimed |
| US-20110217265-A1 | Screening for Inhibitors of HCV Amphipathic Helix (AH) Function | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-08 | — | — | US | disclosed |
| WO-2010039195-A2 | SCREENING FOR INHIBITORS OF HCV AMPHIPATHIC HELIX (AH) FUNCTION | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110217265-A1 | Screening for Inhibitors of HCV Amphipathic Helix (AH) Function | NSF, HAVCR2, ABHD16A | GRM5 3805/4885PIM2 4471/4885PIM1 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.