Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | ATR | Q13535 | 8/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12288580 | 0.95 | HDAC6 (0.55) | HDAC6KDM4EALDH1A1TP53HPGD | |
| Trifluoroacetic Acid SCHEMBL2430086 | 0.87 | HDAC6 (0.48) | HDAC6KDM4EALDH1A1TP53HPGD | |
| Trifluoroacetic Acid SCHEMBL2432097 | 0.86 | HDAC6 (0.49) | HDAC6KDM4EALDH1A1TP53HPGD | |
| Trifluoroacetic Acid SCHEMBL2434092 | 0.85 | HDAC6 (0.50) | HDAC6KDM4EALDH1A1TP53HPGD | |
| SCHEMBL12288566 | 0.81 | HDAC6 (0.52) | HDAC6KDM4EALDH1A1TP53HPGD | |
| SCHEMBL3124284 | 0.80 | HDAC6 (0.54) | HDAC6KDM4EALDH1A1TP53HPGD | |
| SCHEMBL12288568 | 0.79 | HDAC6 (0.55) | HDAC6KDM4EALDH1A1TP53HPGD | |
| Trifluoroacetic Acid SCHEMBL2434892 | 0.79 | PLAU (0.53) | GRM5ATR | |
| SCHEMBL12288501 | 0.77 | TP53 (0.52) | HDAC6KDM4EALDH1A1TP53HPGD | |
| Trifluoroacetic Acid SCHEMBL2428006 | 0.77 | GRM5 (0.54) | HDAC6KDM4EALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110217265-A1 | Screening for Inhibitors of HCV Amphipathic Helix (AH) Function | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-08 | — | — | US | claimed |
| US-20110217265-A1 | Screening for Inhibitors of HCV Amphipathic Helix (AH) Function | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-08 | — | — | US | disclosed |
| WO-2010039195-A2 | SCREENING FOR INHIBITORS OF HCV AMPHIPATHIC HELIX (AH) FUNCTION | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110217265-A1 | Screening for Inhibitors of HCV Amphipathic Helix (AH) Function | NSF, HAVCR2, ABHD16A | HDAC6 1395/4885KDM4E 3652/4885ALDH1A1 2579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.