Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | RHEB | Q15382 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682076 | 0.85 | ALDH1A1 (0.64) | HTTLMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4243540 | 0.83 | HSP90AA1 (0.69) | HTTLMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6217370 | 0.82 | HTT (0.64) | HTTLMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1097139 | 0.82 | HTT (0.64) | HTTLMNAKDM4EALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7324046 | 0.82 | HSP90AA1 (0.68) | HTTLMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL28396605 | 0.82 | HTT (0.64) | HTTLMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL30349840 | 0.81 | ALDH1A1 (0.64) | HTTLMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6088752 | 0.81 | ALDH1A1 (1.00) | HTTLMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL27978054 | 0.81 | TDP1 (0.66) | ALDH1A1MMP2MMP9MMP8MMP13 | |
| SCHEMBL20982471 | 0.81 | MMP2 (0.78) | HTTLMNAKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022074617-A1 | COMBINATION OF ANTIBODY-DRUG CONJUGATE AND PARP1 SELECTIVE INHIBITOR | ASTRAZENECA UK LIMITED (GB) | 2022-04-14 | — | — | WO | disclosed |