Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MMP12 | P39900 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904365 | 1.00 | MMP9 (0.46) | MMP9MMP12MMP2MMP1ALDH1A1 | |
| SCHEMBL2421717 | 0.98 | MMP9 (0.43) | MMP9MMP12MMP2MMP1ALDH1A1 | |
| SCHEMBL28413511 | 0.81 | HTT (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31229951 | 0.77 | NPC1 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2425813 | 0.75 | JAK3 (0.47) | ALDH1A1MAPTSMN1; SMN2NPSR1NPC1 | |
| SCHEMBL5317101 | 0.73 | — | — | |
| SCHEMBL2418976 | 0.73 | JAK3 (0.44) | ALDH1A1LMNASMN1; SMN2NPSR1NPC1 | |
| SCHEMBL179869 | 0.72 | NPC1 (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14335035 | 0.72 | GLA (0.52) | NPC1RAB9A | |
| SCHEMBL3682800 | 0.71 | SMN1; SMN2 (0.56) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |