Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2423520 | 0.82 | NPC1 (0.45) | NPC1RAB9AKMT2AALDH1A1KDM4E | |
| SCHEMBL2321138 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL26916942 | 0.80 | NPC1 (0.49) | NPC1RAB9AKMT2AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL26916941 | 0.80 | NPC1 (0.49) | NPC1RAB9AKMT2AALDH1A1KDM4E | |
| SCHEMBL5161099 | 0.77 | KDM4E (0.44) | NPC1RAB9AKMT2AALDH1A1KDM4E | |
| SCHEMBL7574578 | 0.77 | NPC1 (0.46) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2421709 | 0.76 | KMT2A (0.42) | NPC1RAB9AKMT2ATAAR1 | |
| SCHEMBL29163121 | 0.75 | NPC1 (0.47) | NPC1RAB9AKMT2AALDH1A1KDM4E | |
| SCHEMBL152733 | 0.75 | NUDT1 (0.49) | NPC1RAB9AKMT2AALDH1A1KDM4E | |
| 1,2-Dichloroethane SCHEMBL28029710 | 0.75 | NPC1 (0.45) | NPC1RAB9AKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |