Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28606687 | 0.80 | ADORA3 (0.43) | KMT2AADORA3ADORA2AADORA1NPC1 | |
| SCHEMBL7402248 | 0.80 | ALOX15 (0.50) | KMT2AMAPTNPC1RAB9A | |
| SCHEMBL6037395 | 0.80 | KMT2A (0.47) | KMT2ATAAR1MAPTNPC1RAB9A | |
| SCHEMBL432658 | 0.79 | TDP1 (0.53) | KMT2ATAAR1TSHRRAB9AL3MBTL1 | |
| SCHEMBL6432858 | 0.78 | KMT2A (0.46) | KMT2ATAAR1MAPTNPC1RAB9A | |
| SCHEMBL2428402 | 0.76 | NPC1 (0.42) | KMT2ATAAR1NPC1RAB9A | |
| SCHEMBL31752166 | 0.75 | NPC1 (0.54) | NPC1RAB9A | |
| SCHEMBL2167257 | 0.74 | POLB (0.50) | KMT2ATAAR1TSHRNPC1RAB9A | |
| Formaldehyde SCHEMBL27478953 | 0.74 | TAAR1 (0.57) | TAAR1TSHRNSD2ABL1PPARG | |
| SCHEMBL231282 | 0.73 | TSHR (0.61) | KMT2ATSHRMAPTGRM5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |