Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 12/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | PKLR | P30613 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | RORA | P35398 | 1/20 | 0.45 |
| ▸ | RORB | Q92753 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286347 | 0.93 | RORC (0.64) | RORCNPC1PKMPKLRNR1I2 | |
| SCHEMBL24286755 | 0.93 | RORC (0.59) | RORCNPC1PKMPKLRNR1I2 | |
| SCHEMBL24286172 | 0.90 | RORC (0.66) | RORCNPC1PKMPKLRNR1I2 | |
| SCHEMBL24286496 | 0.89 | RORC (0.54) | RORCNPC1PKMPKLRNR1I2 | |
| SCHEMBL24286631 | 0.89 | RORC (0.55) | RORCNPC1PKMPKLRNR1I2 | |
| SCHEMBL24286727 | 0.89 | PKM (0.53) | RORCPKMPKLRKMT2APAX8 | |
| SCHEMBL24286390 | 0.89 | PKM (0.57) | RORCPKMPKLRKMT2APAX8 | |
| SCHEMBL24286545 | 0.87 | RORC (0.62) | RORCPKMPKLRCYP11B1CYP11B2 | |
| SCHEMBL24286832 | 0.87 | PKM (0.50) | RORCPKMPKLRKMT2APAX8 | |
| SCHEMBL24286383 | 0.86 | PKM (0.53) | RORCPKMPKLRNR1I2RORA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |