Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 8/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286694 | 0.86 | RORC (0.52) | PKMPKLRHTR6CYP11B1CYP11B2 | |
| SCHEMBL24286236 | 0.85 | PKM (0.52) | PKMPKLRCYP11B1CYP11B2RORC | |
| SCHEMBL24286552 | 0.84 | RORC (0.44) | PKMPKLRHTR6CYP11B1CYP11B2 | |
| SCHEMBL24286226 | 0.83 | RORC (0.51) | PKMPKLRHTR6CYP11B1CYP11B2 | |
| SCHEMBL24286803 | 0.82 | RORC (0.49) | PKMPKLRHTR6RORCNR1H3 | |
| SCHEMBL24286648 | 0.81 | RORC (0.52) | PKMPKLRHTR6RORCHTT | |
| SCHEMBL24286445 | 0.81 | RORC (0.54) | PKMPKLRHTR6CYP11B1CYP11B2 | |
| SCHEMBL24286434 | 0.81 | RORC (0.55) | PKMPKLRHTR6RORC | |
| SCHEMBL24287126 | 0.80 | RORC (0.41) | PKMPKLRHTR6RORC | |
| SCHEMBL20957350 | 0.78 | RORC (0.64) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |