Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 13/20 | 0.48 |
| ▸ | CPT1A | P50416 | 4/20 | 0.46 |
| ▸ | CPT2 | P23786 | 2/20 | 0.46 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286530 | 0.90 | RORC (0.51) | KMT2ARORCPKMPKLR | |
| SCHEMBL24286832 | 0.89 | PKM (0.50) | CYP3A4CYP2D6MEN1TP53MAPT | |
| SCHEMBL24286485 | 0.89 | RORC (0.52) | RORCCPT1ACPT2PKMPKLR | |
| SCHEMBL24286707 | 0.89 | RORC (0.55) | RORCCPT1ACPT2CPT1BPKM | |
| SCHEMBL24286199 | 0.89 | RORC (0.55) | RORCCPT1ACPT2CPT1BPKM | |
| SCHEMBL24286635 | 0.87 | RORC (0.53) | RORCCPT1ACPT2CPT1BPKM | |
| SCHEMBL24287165 | 0.86 | RORC (0.47) | KMT2ARORCPKMPKLR | |
| SCHEMBL24286545 | 0.86 | RORC (0.62) | RORCCPT1ACPT2PKMPKLR | |
| SCHEMBL24286641 | 0.85 | RORC (0.55) | KMT2ARORCPKMPKLR | |
| SCHEMBL24286198 | 0.85 | RORC (0.63) | RORCCPT1ACPT2CPT1BPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |