Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286750 | 0.88 | PARP10 (0.42) | TDP2PYGLHRH3PARP10PARP1 | |
| SCHEMBL24286723 | 0.86 | PYGL (0.50) | TDP2PYGLHRH3PARP10PARP1 | |
| SCHEMBL24287001 | 0.84 | PARP1 (0.44) | PYGLHRH3PARP1KDM4EALDH1A1 | |
| SCHEMBL3112268 | 0.82 | PYGL (0.49) | PYGLHRH3PARP10PARP1KDM4E | |
| SCHEMBL29622425 | 0.82 | PYGL (0.49) | PYGLHRH3PARP10PARP1KDM4E | |
| SCHEMBL24287059 | 0.82 | PYGL (0.39) | TDP2PYGLHRH3PARP10PARP1 | |
| Hydrochloric Acid SCHEMBL30142485 | 0.81 | PYGL (0.48) | PYGLHRH3PARP10PARP1KDM4E | |
| Hydrochloric Acid SCHEMBL2144161 | 0.81 | PYGL (0.48) | PYGLHRH3PARP10PARP1KDM4E | |
| SCHEMBL24287074 | 0.79 | PARP10 (0.50) | PYGLHRH3PARP10KDM4EMEN1 | |
| SCHEMBL24287049 | 0.78 | PGR (0.41) | PYGLHRH3PARP10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |