Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463624 | 0.91 | PAM (0.39) | PAMKDM4EMAPTTHRBALOX15 | |
| SCHEMBL2429383 | 0.83 | KDM4E (0.36) | PAMKDM4EMAPTTHRBALOX15 | |
| SCHEMBL2466567 | 0.79 | PAM (0.38) | PAMKDM4EMAPTTHRBALOX15 | |
| SCHEMBL2403433 | 0.75 | MAPT (0.42) | PAMKDM4EMAPTTHRBALOX15 | |
| SCHEMBL28831487 | 0.75 | MAPT (0.41) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL12308073 | 0.73 | PAM (0.34) | PAMKDM4EMAPTTHRBALOX15 | |
| SCHEMBL2429392 | 0.71 | — | — | |
| SCHEMBL24067699 | 0.70 | MAPT (0.59) | PAMKDM4EMAPTTHRBALOX15 | |
| SCHEMBL308082 | 0.70 | MAPT (0.59) | PAMKDM4EMAPTTHRBALOX15 | |
| SCHEMBL25329304 | 0.70 | MAPT (0.59) | PAMKDM4EMAPTTHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545033-A2 | PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS | Promentis Pharmaceuticals, Inc. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112535-A2 | PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS | PROMENTIS PHARMACEUTICALS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |