Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PAM | P19021 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.33 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dacisteine SCHEMBL1814125 | 0.84 | MAPT (0.55) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| Dacisteine SCHEMBL2402188 | 0.84 | MAPT (0.55) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| SCHEMBL10564990 | 0.82 | MAPT (0.42) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| SCHEMBL4777259 | 0.78 | MAPT (0.39) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| SCHEMBL2403431 | 0.78 | MAPT (0.44) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| SCHEMBL19288035 | 0.77 | MME (0.39) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| SCHEMBL9966095 | 0.77 | KDM4E (0.38) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| SCHEMBL13179778 | 0.77 | MAPT (0.38) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| SCHEMBL6470507 | 0.77 | KDM4E (0.38) | MAPTSMN1; SMN2NFKB1KDM4ETHRB | |
| SCHEMBL5656969 | 0.77 | KDM4E (0.38) | MAPTSMN1; SMN2NFKB1KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545033-A2 | PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS | Promentis Pharmaceuticals, Inc. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112535-A2 | PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS | PROMENTIS PHARMACEUTICALS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |