Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL18740714 | 0.96 | — | — | |
| Piperazine SCHEMBL1083046 | 0.88 | FFAR3 (0.54) | LMNAHIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL7327328 | 0.88 | FFAR3 (0.54) | LMNAHIF1AMAPTPDE4AKDR | |
| Acetic Acid SCHEMBL2907405 | 0.88 | FFAR3 (0.54) | LMNAHIF1AMAPTPDE4AKDR | |
| Acetic Acid SCHEMBL9599616 | 0.88 | FFAR3 (0.54) | LMNAHIF1AMAPTPDE4AKDR | |
| Acetic Acid SCHEMBL3451040 | 0.88 | FFAR3 (0.54) | LMNAHIF1AMAPTPDE4AKDR | |
| Acetic Acid SCHEMBL7118694 | 0.88 | FFAR3 (0.54) | LMNAHIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL8505307 | 0.88 | TSHR (0.54) | LMNAHIF1AMAPTPDE4AKDR | |
| Pyrrolidine SCHEMBL9290837 | 0.85 | — | — | |
| Piperazine SCHEMBL23356456 | 0.85 | FFAR3 (0.50) | LMNAHIF1AMAPTPDE4AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105175421-B | Midbody compound and application thereof for synthesis of selective NK-3 receptor antagonists | 欧歌达有限公司 | 2018-07-13 | — | — | CN | disclosed |
| CN-103906750-B9 | Novel chiral N-acyl-5, 6,7, (8-substituted) -tetrahydro- [1, 2,4] triazolo [4, 3-a ] pyrazines as selective NK-3 receptor antagonists, pharmaceutical compositions, methods for use in NK-3 receptor mediated diseases and chiral synthesis thereof | 欧洲筛选有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-103906750-B | Novel chiral N-acyl-5, 6,7, (8-substituted) -tetrahydro- [1, 2,4] triazolo [4, 3-a ] pyrazines as selective NK-3 receptor antagonists, pharmaceutical compositions, methods for use in NK-3 receptor mediated diseases and chiral synthesis thereof | 欧洲筛选有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-105175421-A | Novel chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor mediated disorders and chiral synthesis thereof | EUROSCREEN SA | 2015-12-23 | — | — | CN | disclosed |
| CN-103906750-A | Novel chiral N-acyl-5, 6,7, (8-substituted) -tetrahydro- [1,2,4] triazolo [4,3-a ] pyrazines as selective NK-3 receptor antagonists, pharmaceutical compositions, methods for use in NK-3 receptor mediated diseases and chiral synthesis thereof | EUROSCREEN SA | 2014-07-02 | — | — | CN | disclosed |
| EP-2550275-A1 | PYRROLO[2,L-C][L,4]BENZODIAZEPINE-BENZOTHIAZOLE OR BENZOXAZOLE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR THE PREPARATION THEREOF | Council Of Scientific & Industrial Research (IN) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011117882-A1 | PYRROLO[2,L-C][L,4]BENZODIAZEPINE-BENZOTHIAZOLE OR BENZOXAZOLE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-09-29 | — | — | WO | disclosed |
| WO-1994000633-A1 | METHODS OF DEINKING CELLULOSIC MATERIALS | NEWPAPER ASSOCIATION OF AMERICA (US) | 1994-01-06 | — | — | WO | disclosed |