Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL2429468 | 0.88 | LMNA (0.50) | TSHRTHPOHIF1AMAPTPDE4A | |
| Piperazine SCHEMBL1083046 | 0.85 | FFAR3 (0.54) | TSHRTHPOHIF1AMAPTPDE4A | |
| Acetic Acid SCHEMBL7118694 | 0.85 | FFAR3 (0.54) | TSHRTHPOHIF1AMAPTPDE4A | |
| Acetic Acid SCHEMBL2907405 | 0.85 | FFAR3 (0.54) | TSHRTHPOHIF1AMAPTPDE4A | |
| Acetic Acid SCHEMBL9599616 | 0.85 | FFAR3 (0.54) | TSHRTHPOHIF1AMAPTPDE4A | |
| Piperazine SCHEMBL7327328 | 0.85 | FFAR3 (0.54) | TSHRTHPOHIF1AMAPTPDE4A | |
| Acetic Acid SCHEMBL3451040 | 0.85 | FFAR3 (0.54) | TSHRTHPOHIF1AMAPTPDE4A | |
| Acetone SCHEMBL18740714 | 0.84 | — | — | |
| Piperazine SCHEMBL23356456 | 0.81 | FFAR3 (0.50) | TSHRTHPOHIF1AMAPTPDE4A | |
| Piperazine SCHEMBL3620560 | 0.81 | LMNA (0.57) | TSHRTHPOHIF1AMAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415508-A | Full-size process for preparing polymer powders | 西莫-戴顿有限责任公司 | 2019-03-01 | — | — | CN | claimed |
| CN-107286137-A | Deuterated dehydrogenase 13-benzoyloxy phenyl ahistins class compound and preparation method thereof and the application in anti-tumor drug is prepared | 青岛海洋生物医药研究院股份有限公司 | 2017-10-24 | — | — | CN | claimed |
| CN-106279039-A | Deuterated dehydrophenylahistin compounds and preparation method thereof and the application in preparing anti-tumor drug | 青岛海洋生物医药研究院股份有限公司 | 2017-01-04 | — | — | CN | claimed |
| CN-104144968-A | Low toxicity solvent system for polyamideimide resins and preparation of solvent system | FUJIFILM HUNT CHEMICALS US INC | 2014-11-12 | — | — | CN | claimed |
| EP-4745283-A1 | FLASH-SPUN POLYETHYLENE FILM MATERIAL WITH GOOD TOUGHNESS AND MANUFACTURING METHOD THEREFOR | Kingwills Advanced Materials Co., Ltd. (CN) | 2026-05-20 | — | — | EP | disclosed |
| CN-116590846-B | Flash-spun polyethylene film material with better toughness and manufacturing method thereof | 江苏青昀新材料有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116590846-A | Flash-spun polyethylene film material with better toughness and manufacturing method thereof | 江苏青昀新材料有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-115960862-A | Cutinase mutant and application thereof in synthesis of 1, 4-diacetylpiperazine | 中国科学院青岛生物能源与过程研究所 | 2023-04-14 | — | — | CN | disclosed |
| CN-109563079-A | Polymorphic form of dehydrophenylahistine compound, preparation and purification method and application thereof | 青岛海洋生物医药研究院股份有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109415510-A | PAI-based coating composition | 西莫-戴顿有限责任公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109415508-A | Full-size process for preparing polymer powders | 西莫-戴顿有限责任公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-106279039-B | Deuterated dehydrophenylahistin class compound and preparation method thereof and preparing the application in anti-tumor drug | 青岛海洋生物医药研究院股份有限公司 | 2019-01-11 | — | — | CN | disclosed |
| CN-1759637-A | Electroluminescent element | MITSUBISHI CHEM CORP (JP) | 2006-04-12 | — | — | CN | disclosed |
| US-5877270-A | Water solvent extraction degreasing method and molded products produced therewith | KABUSHIKI KAISHA KOMATSU SEISAKUSHO (JP) | 1999-03-02 | — | — | US | disclosed |
| EP-0809556-B1 | BINDER FOR USE IN METAL POWDER INJECTION MOLDING AND DEBINDING METHOD BY THE USE OF THE SAME | KOMATSU MFG CO LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0809556-A1 | BINDER FOR USE IN METAL POWDER INJECTION MOLDING AND DEBINDING METHOD BY THE USE OF THE SAME | KOMATSU LTD. (JP) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025261-A1 | BINDER FOR USE IN METAL POWDER INJECTION MOLDING AND DEBINDING METHOD BY THE USE OF THE SAME | KOMATSU LTD. (JP) | 1996-08-22 | — | — | WO | disclosed |
| EP-0068866-B1 | METHOD OF MANUFACTURING ACETONE OR METHYL ETHYL KETONE | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-07-24 | — | — | EP | disclosed |
| US-4401708-A | POLYESTER AND NYLON FIBERS | STANDARD OIL COMPANY (INDIANA) (US) | 1983-08-30 | — | — | US | disclosed |
| EP-0068866-A1 | Method of manufacturing acetone or methyl ethyl ketone | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1983-01-05 | — | — | EP | disclosed |