Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29078026 | 1.00 | MRGPRX2 (0.55) | MRGPRX2CARM1PRMT6MAPK14HSPB1 | |
| SCHEMBL30473701 | 1.00 | MRGPRX2 (0.55) | MRGPRX2CARM1PRMT6MAPK14HSPB1 | |
| SCHEMBL31133294 | 1.00 | MRGPRX2 (0.55) | MRGPRX2CARM1PRMT6MAPK14HSPB1 | |
| SCHEMBL31132457 | 0.87 | MRGPRX2 (0.43) | MRGPRX2ALDH1A1RAB9AACACBRAF1 | |
| SCHEMBL27211501 | 0.87 | MRGPRX2 (0.43) | MRGPRX2ALDH1A1RAB9AACACBRAF1 | |
| SCHEMBL29563814 | 0.87 | MRGPRX2 (0.43) | MRGPRX2ALDH1A1RAB9AACACBRAF1 | |
| SCHEMBL29564440 | 0.85 | MRGPRX2 (0.42) | MRGPRX2ACACB | |
| SCHEMBL27211370 | 0.85 | MRGPRX2 (0.42) | MRGPRX2ACACB | |
| SCHEMBL31510724 | 0.85 | MRGPRX2 (0.41) | MRGPRX2MAPK14ALDH1A1RAB9AACACB | |
| SCHEMBL29564421 | 0.85 | MRGPRX2 (0.41) | MRGPRX2MAPK14ALDH1A1RAB9AACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116390917-A | MRGX2 antagonists | 葛兰素史密斯克莱知识产权发展有限公司 | 2023-07-04 | — | — | CN | disclosed |
| WO-2022073905-A1 | MRGX2 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-14 | — | — | WO | disclosed |