Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | GCK | P35557 | 8/20 | 0.34 |
| ▸ | RAF1 | P04049 | 3/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29563814 | 1.00 | MRGPRX2 (0.43) | MRGPRX2IDO1GCKRAF1MAPK3 | |
| SCHEMBL27211501 | 1.00 | MRGPRX2 (0.43) | MRGPRX2IDO1GCKRAF1MAPK3 | |
| SCHEMBL29078026 | 0.87 | MRGPRX2 (0.55) | MRGPRX2IDO1GCKRAF1MAPK3 | |
| SCHEMBL31133294 | 0.87 | MRGPRX2 (0.55) | MRGPRX2IDO1GCKRAF1MAPK3 | |
| SCHEMBL30473701 | 0.87 | MRGPRX2 (0.55) | MRGPRX2IDO1GCKRAF1MAPK3 | |
| SCHEMBL24297738 | 0.87 | MRGPRX2 (0.55) | MRGPRX2IDO1GCKRAF1MAPK3 | |
| SCHEMBL31132482 | 0.83 | CARM1 (0.43) | MRGPRX2IDO1TDP1BRAFACACB | |
| SCHEMBL27211370 | 0.83 | MRGPRX2 (0.42) | MRGPRX2TDP1ACACB | |
| SCHEMBL29564440 | 0.83 | MRGPRX2 (0.42) | MRGPRX2TDP1ACACB | |
| SCHEMBL31510724 | 0.83 | MRGPRX2 (0.41) | MRGPRX2IDO1GCKTDP1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704830-A2 | MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF | Septerna, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024226914-A2 | MRGPRX2 ANTAGONISTS AND METHODS OF USE THEREOF | SEPTERNA, INC. (US) | 2024-10-31 | — | — | WO | disclosed |