Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2082531 | 0.91 | CYP4F2 (0.51) | MAPTSIRT2SYKCYP4F2CYP4A11 | |
| SCHEMBL11069047 | 0.83 | KMT2A (0.49) | MAPTSYKCYP4F2CYP4A11PPARG | |
| SCHEMBL2082850 | 0.82 | HTT (0.44) | MAPTSYKALDH1A1F10 | |
| SCHEMBL11066194 | 0.81 | NPC1 (0.46) | MAPTCYP4F2CYP4A11PPARGPPARA | |
| SCHEMBL4326400 | 0.81 | FFAR1 (0.48) | MAPTALDH1A1ALOX5 | |
| SCHEMBL4151444 | 0.81 | TAAR1 (0.45) | MAPTCYP4F2CYP4A11PPARGPPARA | |
| Hydrochloric Acid SCHEMBL2082848 | 0.81 | MAPT (0.46) | MAPTSYKALDH1A1F10 | |
| SCHEMBL3193808 | 0.80 | SIRT2 (0.62) | MAPTSIRT2CYP4F2CYP4A11BRD4 | |
| SCHEMBL717900 | 0.80 | TDP1 (0.56) | MAPTCYP4F2CYP4A11ALDH1A1ABCB1 | |
| SCHEMBL7159712 | 0.78 | CYP4F2 (0.64) | CYP4F2CYP4A11ABCB1ALOX5OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220098171-A1 | 5-(4-PYRIDYLOXY)PYRAZOLE COMPOUNDS SERVING AS TGF-ßR1 KINASE INHIBITOR | JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. (CN) | 2022-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220098171-A1 | 5-(4-PYRIDYLOXY)PYRAZOLE COMPOUNDS SERVING AS TGF-ßR1 KINASE INHIBITOR | TGFBR1, TGFBR2, TGFB1 | MAPT 2338/4885SIRT2 2295/4885SYK 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.