Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18167877 | 0.77 | STK17B (0.37) | LMNAKMT2ASTK17BSTK17AHSP90AA1 | |
| SCHEMBL22509297 | 0.76 | PAX8 (0.39) | LMNAKMT2ASTK17BSTK17AHSP90AA1 | |
| SCHEMBL1369098 | 0.75 | APP (0.37) | LMNAKMT2AUSP30 | |
| SCHEMBL22502038 | 0.74 | STK17B (0.35) | LMNAKMT2ASTK17BSTK17AHSP90AA1 | |
| SCHEMBL24323341 | 0.70 | STK17B (0.38) | LMNAKMT2ASTK17BSTK17AHSP90AA1 | |
| SCHEMBL24332234 | 0.70 | — | — | |
| SCHEMBL8819965 | 0.70 | SYK (0.35) | LMNAKMT2ASTK17BSTK17AHSP90AA1 | |
| SCHEMBL4439238 | 0.70 | SMN1; SMN2 (0.36) | LMNAKMT2ASTK17BSTK17AHSP90AA1 | |
| SCHEMBL4555591 | 0.69 | TAS1R3 (0.39) | LMNAKMT2ASTK17BSTK17AHSP90AA1 | |
| SCHEMBL23340797 | 0.69 | AAK1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076621-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |