Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | KDM5C | P41229 | 4/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4A | O75164 | 3/20 | 0.39 |
| ▸ | KDM6B | O15054 | 3/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28786825 | 0.83 | LMNA (0.47) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| SCHEMBL30527973 | 0.81 | KDM4C (0.61) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| SCHEMBL40395 | 0.81 | KDM4C (0.61) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| SCHEMBL30396251 | 0.79 | KDM1A (0.44) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| SCHEMBL30595888 | 0.79 | KDM1A (0.44) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| Hydrochloric Acid SCHEMBL29188716 | 0.79 | KDM4C (0.59) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| SCHEMBL3127472 | 0.79 | PARP1 (0.48) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| SCHEMBL31026889 | 0.79 | PARP1 (0.48) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| SCHEMBL1137138 | 0.79 | KDM1A (0.44) | KDM1AHDAC1HDAC6KDM4EKDM5C | |
| SCHEMBL220172 | 0.79 | KDM1A (0.44) | KDM1AHDAC1HDAC6KDM4EKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319426-A1 | Substituted Isoindoles | ASTRAZENECA AB (SE) | 2011-12-29 | — | — | US | disclosed |
| US-8030500-B2 | Substituted isoindoles for the treatment and/or prevention of Aβ- related pathologies | ASTRAZENECA AB (SE) | 2011-10-04 | — | — | US | disclosed |
| EP-2367814-A1 | NEW COMPOUNDS 578 | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| US-20100125082-A1 | NEW COMPOUNDS 578 | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | US | disclosed |
| WO-2010056196-A1 | NEW COMPOUNDS 578 | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125082-A1 | NEW COMPOUNDS 578 | PSEN1, PSEN2, BACE1 | KDM1A 3861/4885HDAC1 2806/4885HDAC6 821/4885 |
| US-20110319426-A1 | Substituted Isoindoles | PSEN2, PSEN1, SNCA | KDM1A 4227/4885HDAC1 3048/4885HDAC6 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.