Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA7 | P43166 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19489529 | 0.78 | TSHR (0.34) | TSHRCYP3A4TP53ALDH1A1MAPK1 | |
| SCHEMBL19489638 | 0.75 | TSHR (0.32) | TSHRCYP3A4TP53ALDH1A1MAPK1 | |
| SCHEMBL19636756 | 0.75 | ALDH1A1 (0.37) | TSHRCYP3A4ALDH1A1MAPK1ALOX15 | |
| SCHEMBL27358536 | 0.75 | ALDH1A1 (0.43) | TSHRCYP3A4TP53ALDH1A1MAPK1 | |
| SCHEMBL24879335 | 0.75 | CA12 (0.31) | CA12CA1CA2CA7CA9 | |
| SCHEMBL24934263 | 0.75 | ALDH1A1 (0.38) | TSHRCYP3A4ALDH1A1MAPK1CA12 | |
| SCHEMBL21230438 | 0.73 | GAA (0.37) | CA12CA1CA2CA7CA9 | |
| SCHEMBL21230370 | 0.71 | CD44 (0.38) | ALDH1A1CA1CA2CA9 | |
| SCHEMBL7209297 | 0.70 | TSHR (0.39) | TSHRCYP3A4TP53ALDH1A1MAPK1 | |
| SCHEMBL11026968 | 0.70 | TSHR (0.39) | TSHRCYP3A4TP53ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022064459-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1ST Biotherapeutics, Inc. (KR) | 2022-03-31 | — | — | WO | disclosed |