Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309693 | 0.82 | IRAK4 (0.33) | CHEK1CREBBP | |
| SCHEMBL24309680 | 0.82 | IRAK4 (0.33) | CHEK1CREBBP | |
| SCHEMBL24309788 | 0.79 | GCK (0.36) | AXLCHEK1TYRO3CCNA2CDK2 | |
| SCHEMBL24310582 | 0.78 | CYP1A2 (0.34) | TYRO3AURKB | |
| SCHEMBL24309828 | 0.77 | AXL (0.33) | AXLTYRO3 | |
| SCHEMBL24309306 | 0.75 | NLRP3 (0.38) | AXLCREBBPKDRCDK2 | |
| SCHEMBL24309692 | 0.74 | NLRP3 (0.39) | CREBBPKDRCDK2 | |
| SCHEMBL24309932 | 0.74 | CCNT1 (0.33) | CDK2 | |
| SCHEMBL24310706 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL24309898 | 0.71 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |